My entire career has focused on understanding the human bone remodeling process under both physiological and pathophysiological conditions, including aging, osteoporosis, bone metastasis, multiple myeloma and rare genetic disorders, as well as the effect of bone-targeting treatments. My research has contributed significantly to advancing our understanding of the human bone remodeling, reshaping our fundamental understanding of its cellular organization, pathophysiological dysfunction, and response to bone-targeting treatments. I head the Molecular Bone Histology (MBH) lab (www.mbhlab.dk) and the Danish Spatial Imaging Consortium (DanSIC) infrastructure (www.dansic.dk), which span the University of Southern Denmark (SDU), Odense University Hospital (OUH) and Aarhus University (AU). My MBH lab and DanSIC infrastructure possess leading-edge expertise and state-of-art equipment in advanced molecular histology including spatial profiling technologies as GeoMx and Xenium, with particular strengths in bone and other calcified tissues. My research is interdisciplinary and spans multiple modalities, integrating my advanced molecular histology with mathematics, engineering, physics, an both ex vivo and in vivo models, as well as multi-omics approaches, linking spatial transcriptomics with epigenetics, bulk transcriptomics and proteomics, facilitated by applied infrastructure.