PUBLICATIONS

2026

Intratrabecular bone remodeling - a previously overlooked mode of remodeling hyperactivated by parathyroid hormone

JBMR

Thomsen LK, Laursen KS, Sikjær T, Thomsen JS, Andreasen CM, Loundagin L, Harrison K, Underbjerg L, Boel LWT, Hansen D, Dempster D, Cosman F, Wei X, Rizvi AR, Kersh M, Cooper DML, Rejnmark L, Andersen TL*

2026

An ITGA11-expressing subpopulation as predictor for the donor-specific osteogenic capacity of stromal cells

Bone Res.

Rauch A, Jamil A, Jeromdesella S, Madsen K, Nørgård M, Grupe E, Jakobsson M, Kassem M, Daamouch S, Villadsen B, Andersen TL, Ma C, Takematsu E, Zhao L, Goodman S, Goodnough L, Wang Y

2026 Feb

Uncoupled bone remodeling drives myeloma bone disease in Vk*MYC mouse model of multiple myeloma

Bone Rep.

Schmal C, Simic MK, Xiao Y, Catala AA, Jiang M, Andersen TL, Diaz-delCastillo M, Croucher P, McDonald M, Jafari A

2025 Dec

Ixazomib treatment has a dual effect on bone remodeling in patients with multiple myeloma: follow-up results from a phase 2 clinical study

Bone

Levring MB, Diaz-delCastillo M, Gundesen MT, Cédile O, Andersen CW, Nielsen AL, Møller HEH, Vinholt PJ, Asmussen JT, Kristensen IB, Nyvold CG, Kassem M, Abildgaard N, Andersen TL*, Lund T*

2025 Dec

The cellular effect of intermittent PTH treatment on bone remodeling and modeling in humans – a histomorphometry centered scoping review

Osteoporos Int.

Thomsen LK, Christiansen PD, Andreasen CM, Andersen TL*

2025 Nov

Denosumab treatment of osteoporotic women arrests cortical bone remodeling events at the reversal-resorption phase but does not affect ongoing bone formation

JBMR Plus

Dahl XG, Roux JP, Delaisse JM, Huang S, Chavassieux P, Andreasen CM, Andersen TL*

2025 Oct

Severe osteoporosis in Larsen syndrome – a case report of bone morphology and a novel Filamin B (FLNB) variant

Calcif Tissue Int.

Juul TM, Thomsen LK, Andreasen CM, Ejersted C, Folkestad L, Brusgaard K, Hansen S, Thomsen JS, Andersen TL*, Frederiksen AL*

2025 Apr

KIAA1199 (CEMIP) regulates adipogenesis and whole-body energy metabolism

Bone Res.

Chen L, Shi K, Ditzel N, Qiu W, Tencerova M, Nielsen LHD, Figeac F, Rauch A, Liu Y, Tao J, Sramkova V, Rossmeislova L, Kerckhofs G, Parac-Vogt TN, de Bournonville S, Andersen TL, Rydén M, Kassem M

2025 Mar

Senescence profiling of monoclonal gammopathies reveals paracrine senescence as a crucial defense against disease progression

Leukemia

Borges GA, Diaz-delCastillo M, Guilatco AJ, El-Masri BM, Mustapha FA, Gundesen MT, Hinge M, Lund T, Abdallah N, Baughn LB, Xu M, Gingery A, Tchkonia T, Kirkland JL, Kourelis T, Drake MT, Andersen TL*, Weivoda MM*

2025 Jan

Type 2 diabetes patients exhibit delayed but coupled bone remodelling, maintaining cortical porosity comparable to healthy controls: A histomorphometric analysis of trans-iliac bone biopsies

Bone

Andreasen CM, Wölfel EM, Ejersted C, Andersen TL*, Frost M*

2025 Jan

Pharmacological blocking of microfibrillar-associated protein 4 reduces retinal neoangiogenesis and vascular leakage

Mol Ther.

Schlosser A, Pilecki B, Allen C, Benest AV, Lynch AP, Hua J, Ved N, Blackley Z, Andersen TL, Hennig D, Graversen JH, Möller S, Skallerup S, Ormhøj M, Lange C, Agostini HT, Grauslund J, Heegaard S, Dacheva I, Koss M, Hu W, Iglesias B, Lawrence MS, Beck HC, Steffensen LB, Laursen NS, Andersen GR, Holmskov U, Bates DO, Sorensen GL

2024 Dec

Multidisciplinary team approach for CKD-associated osteoporosis proposed by the CKD-MBD Working Group of the ERA

Nephrol Dial Transplant

Hansen D, Jørgensen SK, Andersen TL, Ferreira AC, Ferreira A, Jongh R, Keronen S, Kröger H, Lafage-Proust MH, Martola L, Pool KES, Tong X, Evenepol P, Haarhaus M. Behalf of the European Renal Osteodystrophy Working Group (EUROD)

2024 Dec

The ribotoxic stress response drives inflammation and epidermal thickening in UV-irradiated skin in vivo

Mol Cell

Vind AC, Wu Z, Firdaus MJ, Snieckute G, Ann TG, Jessen M, Martínez JF, Haahr P, Andersen TL, Blasius M, Maartensson NL, Gyrd-Hansen M, Zhong FL, Bekker-Jensen S

2024 Nov

Trabecular bone structural units and their cement lines change with age, bone volume fraction, structure, and strength in female human vertebrae

JBMR Plus

Lamarche BA, Thomsen JS, Andreasen CM, Andersen TL*, Lievers WB*

2024 Nov

Novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma

Haematologica

Anloague A, Sabol HM, Kaur J, Khan S, Ashby C, Schinke C, Barnes CL, Alturkmani F, Ambrogini E, Gundesen MT, Lund T, Amstrup AK, Andersen TL, Diaz-delCastillo M, Roodman GD, Bellido T, Delgado-Calle J

2024 Oct

Mapping RANKL- and OPG-expressing cells in bone tissue: The bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect

Bone Res.

El-Masri B, Andreasen CM, Laursen K, Kofod V, Borggaard XG, Nielsen MH, Thomsen JS, Brüel A, Sørensen M, Hansen L, Kim A, Taylor V, Massarotti C, McDonald M, You X, Charles J, Delaisse JM, Andersen TL*

2024 Jun

Celebrating 50-years: the history and future of the International Society of Bone Morphometry

JBMR Plus

Scheller EL, McDonald M, Andersen TL, Sumner DR, Noda M, Erben RG, Boyce BF, Compston JE, Dempster DW, Takahashi HE, Malluche HH, Wronski TJ

2024 Mar

How osteons form: A quantitative hypothesis-testing analysis of cortical pore filling and wall asymmetry

Bone

Hegarty-Cremer SGD, Borggaard XG, Andreasen CM, van der Eerden BCJ, Simpson MJ, Andersen TL*, Buenzli PR*

2024 Mar

Case report: Death caused by multi-organ metastatic calcifications as a result of intramuscular injections with paraffin oil

Bone Rep.

Jakobsen SR, Diaz-delCastillo M, Jensen MB, Andersen TL, Eldrup E, Nielsen TS

2024 Jan

Bone marrow adipocytes provide early sign for progression from MGUS to Multiple Myeloma

Oncotarget

El-Masri B, Leka B, Mustapha F, Gundesen MT, Hinge M, Lund T, Andersen TL*, Diaz-delCastillo M*, Jafari A*

International Invited Talks, 2026

Invited talks by Prof. Thomas L. Andersen

Gordon Conference on Bone and Teeth	Mapping RANKL and OPG-Expressing Cells in Bone and Their Role in the Rebound upon Denosumab Discontinuation
Rush University Chicago, US	The cellular organization and regulation of bone remodeling
The 35th NVCB Annual Meeting Netherlands	The cellular organization and regulation of bone remodeling
Baltic Bone Seminar Helsinki, Finland	Osteoprogenitors central key role in the bone remodeling process
European Calcified Tissue Society (ECTS) Girona, Spain	Mapping Bone Remodeling: Cellular Cartography and Its Regulation with Spatially Resolved Transcriptomics

2023 Dec

How osteons form: A quantitative hypothesis-testing analysis of cortical pore filling and wall asymmetry

Bone

Solene G. D. Hegarty-Cremer, Xenia G. Borggaard, Christina M. Andreasen, Bram C. J. van der Eerden, Matthew J. Simpson, Thomas L. Andersen, Pascal R. Buenzli

2023 Dec

How osteons form: A quantitative hypothesis-testing analysis of cortical pore filling and wall asymmetry

Bone

Solene G. D. Hegarty-Cremer, Xenia G. Borggaard, Christina M. Andreasen, Bram C. J. van der Eerden, Matthew J. Simpson, Thomas L. Andersen, Pascal R. Buenzli

2023 Nov

Novel Developments in the Treatment of Multiple Myeloma-Associated Bone Disease

Cancers

Martin Johansen, Mette Bøegh Levring, Kasper Stokbro, Marta Diaz-delCastillo, Abdul Ahad Khan, Line Adsbøll Wickstroem, Michael Tveden Gundesen, Ida Bruun Kristensen, Charlotte Guldborg Nyvold, Mikkel Østerheden Andersen, Thomas Levin Andersen, Niels Abildgaard, and Thomas Lund

2023 Oct

Disturbed bone marrow adiposity in patients with Cushing’s syndrome and glucocorticoid- and postmenopausal- induced osteoporosis

Front. Endocrinol Nina N. Sørensen, Christina M. Andreasen,Christina M. Andreasen, Pia R. JensenPia R. Jensen, Ellen M. Hauge,Ellen M. Hauge6, Jens Bollerslev,Jens Bollerslev, Jean-Marie Delaiss,Jean-Marie Delaissé, Moustapha Kassem,Moustapha Kassem, Abbas Jafari,Abbas Jafari, Marta Diaz-delCastillo,*Marta Diaz-delCastillo, *Thomas L. Andersen,Thomas L. Andersen

2023 Sept

A systematic review and meta-analysis of thigmotactic behaviour in the open field test in rodent models associated with persistent pain

PLoS One

Xue Ying Zhang, Marta Diaz-delCastillo, Lingsi Kong, Natasha Daniels, William MacIntosh-Smith, Aya Abdallah, Dominik Domanski, Denis Sofrenovic, Tsz
Pui (Skel) Yeung, Diego Valiente, Jan Vollert, Emily Sena, Andrew S. Rice, Nadia SolimanID1*

2023 Aug

Local coordination between intracortical bone remodeling and vascular development in human juvenile bone

Bone

Andreasen CM, El-Masri BM, MacDonald B, Laursen KS, Nielsen MH, Thomsen JS, Delaisse JM, Andersen TL

2023 Jul

Metastatic Infiltration of Nervous Tissue and Periosteal Nerve Sprouting in Multiple Myeloma-Induced Bone Pain in Mice and Human

J Neuroscience

Diaz-delCastillo M, Palasca O, Nemler T, Thygesen D, Chávez-Saldaña N, Vázquez-Mora J, Gomez LP, Jensen L, Evans H, Andrews R, Mandal A, Neves D, Mehlen P, Caruso J, Dougherty P, Price T, Chantry A, Lawson M, Andersen TL, Jimenez-Andrade J, Heegaard AM

2023 Jul

Trabecular bone deterioration in a postmenopausal female suffering multiple spontaneous vertebral fractures due to a delayed denosumab injection – A post treatment re-initiation bone biopsy-based case study

Bone Reports

DDrejer LA, El-Masri BM, Ejersted C, Andreasen CM, Thomsen LK, Thomsen JS, Andersen TL, Hansen S

2023 Jun

A Critical Role of the Bone Marrow Envelope in Human Bone Remodeling

J Bone Miner Res

Andersen TL, Jensen PR, Sikjaer TT, Rejnmark L, Ejersted C, Delaisse JM

2023 Apr

KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration

Nat Commun

Chen L, Shi K, Ditzel N, Qiu W, Figeac F, Nielsen L, Tencerova M, Kowal J, Ding M, Andreasen CM, Andersen TL, Kassem

2023 Mar

Increased bone volume by ixazomib in multiple myeloma: 3-months results from an open label phase 2 study

J Bone Miner Res

Diaz-del Castillo M, Gundesen MT, Andersen CW, Nielsen AL, Møller HEH, Vinholt PJ, Asmussen JT, Kristensen IB, Nyvold CG, Abildgaard N, Andersen TL, Lund T

2023 Jan

GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells

Eur J Endocrinol

Hansen MS, Søe K, Christensen LL, Fernandez-Guerra P, Hansen NW, Wyatt RA, Martin C, Hardy RS, Andersen TL, Olesen JB, Hartmann B, Rosenkilde MM, Kassem M, Rauch A, Gorvin CM, Frost M

2022 Aug

FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder

EMBO Mol Med

Fell CW, Hagelkruys A, Cicvaric A, Horrer M, Liu L, Li JSS, Stadlmann J, Polyansky AA, Mereiter S, Tejada MA, Kokotović T, Achuta VS, Scaramuzza A, Twyman KA, Morrow MM, Juusola J, Yan H, Wang J, Burmeister M, Choudhury B, Andersen TL, Wirnsberger G, Holmskov U, Perrimon N, Žagrović B, Monje FJ, Moeller JB, Penninger JM and Nagy V

2022 Jun

Spatial organization of osteoclastic coupling factors and their receptors at human bone remodeling sites

Frontiers in Molecular Biosciences

Borggaard X, Nielsen M, Delaisse JM, Andreasen CM, Andersen TL

2022 May

Neuronal sprouting and reorganization in bone tissue infiltrated by human breast cancer cells

Frontiers in Pain Research

Hansen RB, Sayilekshmy M, Sørensen MS, Jørgensen AH, Kanneworff IB, Bengtsson E, Grum-Schwensen TA, Petersen MM, Ejersted C, Andersen TL, Andreasen CM, Heegaard A

2022 Apr

Alendronate prolongs the reversal-resorption phase in human cortical bone remodeling

Bone

Borggaard XG, Roux JP, Delaisse JM, Chavassieux P, Andreasen CM, Andersen TL

2022 Mar

2D size of trabecular bone structure units (BSU) correlate more strongly with 3D architectural parameters than age in human vertebrae

Bone

Lamarche BA, Thomsen JS, Andreasen CM, Lievers WB, Andersen TL

2022 Feb

Impaired bone fracture healing in type 2 diabetes is caused by defective functions of skeletal progenitor cells

Stem Cells

Figeac F, Tencerova M, Ali D, Andersen TL, Appadoo DRC, Kerckhofs G, Ditzel N, Kowal JM, Rauch A, Kassem M

2021 Dec

Significance of reversal‐resorption phase in bone loss. Chapter 7. In: Osteoporotic Fracture and Systemic Skeletal Disorders

Takahashi HE, Burr DB, Yamamoto N (Eds.), Springer, Singapore
Andersen TL, Delaisse J-M, Thomsen JS, Andreasen CM

2021 Nov

MFAP4 Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation Through Regulation of Macrophage Infiltration and Activity

Front Cardiovasc Med

Pilecki B, de Carvalho PVSD, Kirketerp-Møller KL, Schlosser A, Kejling K, Dubik M, Madsen NP, Stubbe J, Hansen PBL, Andersen TL, Moeller JB, Marcussen N, Azevedo V, Hvidsten S, Baun C, Shi GP, Lindholt JS, Sorensen GL

2021 Sept

Guidelines for biobanking of bone marrow adipose tissue and related cell types

Frontiers in Endocrinology, section Bone Research

Lucas S, Tencerova M, von der Weid BC, Andersen TL, Attane C, Behler-Janbeck F, Cawthorn WP, Ivaskac KK, Naveiras O, Podgorski I, Reagan MR, van der Eerden BCJ

2021 Aug

RSPO3 is important for trabecular bone and fracture risk in mice and humans

Nat Commun.

Nilsson KH, Henning P, Shahawy ME, Nethander M,Andersen TL, Ejersted C, Wu J, Gustafsson KL, Koskela A, Tuukkanen J, Souza PPC, Tuckermann J, Lorentzon M, Ruud LE, Lehtimäki T, Tobias JH, Zhou S, Lerner UH, Richards JB, Movérare- SkrticS, Ohlsson C

2021 May

Effect of fatigue loading and rest on impact strength of rat ulna

J Biomech

Yan C, Song H, Pfister J, Andersen TL, Warden SJ, Bhargava R, Kersh ME

2021 April

Myeloma-bone marrow adipocyte axis in tumor survival and treatment response

Br. J. Cancer

Jafari A, Fairfield H, Andersen TL, Reagan M

2021 Apr

Bisphosphonates impair the onset of bone formation at remodeling sites

Bone

Jensen PR, Andersen TL^S, Chavassieux P, Roux JP, Delaisse JM

2021 Apr

Human hematopoietic microenvironments

PLoS One

Kristensen HB, Andersen TL^S, Patriarca A, Kallenbach K, MacDonald B, Sikjaer T, Ejersted C, Delaisse JM

2021 Mar

Bone Pain in Multiple Myeloma (BPMM)-A Protocol for a Prospective, Longitudinal, Observational Study

Cancers (Basel)

Diaz-delCastillo M, Andrews RE, Mandal A, Andersen TL, Chantry AD, Heegaard AM

2021 Mar

Modelling cell guidance and curvature control in evolving biological tissues

J Theor Biol

Hegarty-Cremer SGD, Simpson MJ, Andersen TL, Buenzli PR

2021 Mar

The mechanism switching the osteoclast from short to long duration bone resorption

Front Cell Dev Biol

Delaissé JM, Søe K, Andersen TL, Rojek AM, Marcussen N

2021 Jan

Adipocyte-induced transdifferentiation of osteoblasts and its potential role in age-related bone loss

PlosOne

Clabaut A, Grare C, Rolland-Valognes G, Letarouilly JG, Bourrier C, Andersen TL, Sikjær T, Rejnmark L, Ejersted C, Pastoureau P, Hardouin P, Sabatini M, Broux O

2020 Dec

Re-thinking the bone remodeling cycle mechanism and the origin of bone loss

Bone

Delaisse JM, Andersen TL^S, Kristensen HB, Jensen PR, Andreasen CM, Søe K

2020 Aug

PDGF receptor signaling in osteoblast lineage cells controls bone resorption through up-regulation of Csf1 expression

J Bone Miner Res

Brun J, Andreasen CM, Ejersted C, Andersen TL, Caverzasio J, Thouverey C

2020 Mar

Modeling-based bone formation transforms trabeculae to cortical bone in the sclerotic areas in Buschke-Ollendorff syndrome. A case study of two females with LEMD3 variants

Bone

Frost M, Rahbek ET, Ejersted C, Høilund-Carlsen PF, Bygum A, Thomsen JS, Andreasen CM, Andersen TL, Frederiksen AL

2020 Mar

Transcriptional dynamics of hepatic sinusoid-associated cells after liver injury

Hepatology

Terkelsen MK, Bendixen SM, Hansen D, Scott EAH, Moeller AF, Nielsen R, Mandrup S, Schlosser A, Andersen TL, Sorensen GL, Krag A, Natarajan KN, Detlefsen S, Dimke H, Ravnskjaer K

2020 Feb

Myeloma-modified adipocytes exhibit metabolic dysfunction and a senescence-associated secretory phenotype (SASP)

Cancer Res

Fairfield H, Dudakovic A, Khatib CM, Farrell M, Costa S, Falank C, Hinge M, Murphy CS, DeMambro V, Pettitt JA, Lary CW, Driscoll HE, McDonald MM, Kassem M, Rosen C, Andersen TL, van Wijnen AJ, Jafari A, Reagan MR

2020 Jan

Osteoporosis Treatments Affect Bone Matrix Maturation in a Rat Model of Induced Cortical Remodeling

JBMR Plus

Ross RD, Anderson K, Davison R, El‐Masri BM, Andreasen CM, Andersen TL, Sumner DR.

2020 Jan

Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Nat. Commun.

Weivoda MM, Chew CK, Monroe DG, Farr JN, Atkinson EJ, Geske JR, Eckhardt B, Thicke B, Ruan M, Tweed AJ, McCready LK, Rizza RA, Matveyenko A, Kassem M, Andersen TL, Vella A, Drake MT, Clarke BL,Oursler MJ, Khosla S

2019 Nov

The generation of enlarged eroded pores upon existing intracortical canals is a major contributor to endocortical trabecularization

Bone

Andreasen CM, Bakalova LP, Brüel A, Hauge EM, Kiil BJ, Delaisse JM, Kersh ME, Thomsen JS, Andersen TL

2019 Nov

Bone marrow adipose tissue does not express UCP1 during development or adrenergic-induced remodeling

Sci Rep

Craft CS, Robles H, Lorenz MR, Hilker ED, Magee KL, Andersen TL, Cawthorn WP, MacDougald OA, Harris CA, Scheller EL

2019 Nov

High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome

BMC Med Genomics

Moldovan LI, Hansen TB, Venø MT, Okholm TLH, Andersen TL, Hager H, Iversen L, Kjems J, Johansen C, Kristensen LS

2019 Oct

Coordination of Fusion and Trafficking of Pre-osteoclasts at the Marrow-Bone Interface

Calcif Tissue Int

Søe K, Andersen TL, Hinge M, Rolighed L, Marcussen N, Delaisse JM

2019 Mar

Innervation is higher above Bone Remodeling Surfaces and in Cortical Pores in Human Bone: Lessons from patients with primary hyperparathyroidism

Sci Rep.

Sayilekshmy M, Hansen RB, Delaissé JM, Rolighed L, Andersen TL, Heegaard AM

2017 Nov

Understanding age-induced cortical porosity in women: Is a negative BMU balance in quiescent osteons a major contributor?

J. Bone Miner. Res.

Andreasen CM, Delaisse JM, van der Eerden BCJ, van Leeuwen JPTM, Ding M, Andersen TL

2017 Feb

Coupling of Bone Resorption and Formation in Real Time: New Knowledge Gained From Human Haversian BMUs

J. Bone Miner. Res.

Lassen NE, Andersen TL, Ploen GG, Søe K, Hauge EM, Harving S, Eschen GET, Delaisse JM